Masahisa Horiuchi Selected Research

aspartate-glutamate carrier

12/2019	Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.
9/2015	Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency.
5/2006	Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice.
4/2004	Adult-onset type II citrullinemia and idiopathic neonatal hepatitis caused by citrin deficiency: involvement of the aspartate glutamate carrier for urea synthesis and maintenance of the urea cycle.
1/2004	Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia.

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Masahisa Horiuchi Research Topics

Disease

9	Fatty Liver 01/2015 - 09/2002
6	Citrullinemia 08/2007 - 04/2002
5	Adult-onset citrullinemia type 2 12/2019 - 04/2004
5	Cardiomegaly (Heart Hypertrophy) 03/2011 - 09/2002
4	Hyperammonemia 12/2019 - 12/2002
4	Atherosclerosis 01/2014 - 09/2010
4	Body Weight (Weight, Body) 01/2014 - 09/2010
3	Type 2 Diabetes Mellitus (MODY) 05/2021 - 09/2014
3	Hypercholesterolemia 01/2011 - 09/2010
2	Body Weight Changes 01/2023 - 04/2017
2	Diabetic Nephropathies (Diabetic Nephropathy) 03/2018 - 03/2013
2	Fatigue 01/2015 - 02/2013
2	Myeloid Leukemia (Leukemia, Myelocytic) 03/2014 - 01/2012
2	Carcinogenesis 01/2012 - 07/2011
2	Hypoglycemia (Reactive Hypoglycemia) 08/2007 - 12/2002
1	Hemorrhage 01/2022
1	Proteinuria 06/2021
1	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 01/2020
1	Atrial Fibrillation 01/2019
1	Diabetic Retinopathy (Retinopathy, Diabetic) 03/2018
1	Occupational Stress 04/2017
1	Short Qt Syndrome 01/2016
1	Carotid Artery Diseases 05/2015
1	Beriberi 01/2015
1	Narcolepsy 01/2015
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2015
1	Insulin Resistance 09/2014
1	Neoplasms (Cancer) 03/2013
1	Hypoxia (Hypoxemia) 03/2013
1	Malnutrition (Nutritional Deficiencies) 03/2013
1	Hyperglycemia 03/2013
1	Alcoholic Intoxication (Drunkenness) 02/2013
1	Renal Cell Carcinoma (Grawitz Tumor) 07/2011
1	Aplastic Anemia (Anemia, Hypoplastic) 01/2011
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2011
1	Carbamoyl-Phosphate Synthase I Deficiency Disease 06/2009

Drug/Important Bio-Agent (IBA)

10	Carnitine (L-Carnitine)FDA LinkGeneric 01/2016 - 09/2002
7	citrinIBA 12/2019 - 04/2002
5	Glucose (Dextrose)FDA LinkGeneric 06/2021 - 03/2011
5	aspartate-glutamate carrierIBA 12/2019 - 01/2004
4	CarbohydratesIBA 05/2021 - 01/2015
4	Systemic carnitine deficiencyIBA 01/2016 - 12/2002
4	CholesterolIBA 01/2014 - 09/2010
4	Urea (Carbamide)FDA LinkGeneric 05/2006 - 12/2002
3	Proteins (Proteins, Gene)FDA Link 05/2021 - 03/2013
3	Amino Acids FDA Link 05/2021 - 10/2002
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2015 - 11/2009
3	Benzene (Benzole)IBA 03/2014 - 01/2011
3	Messenger RNA (mRNA)IBA 03/2011 - 09/2002
3	Matrix Metalloproteinases (MMPs)IBA 01/2011 - 09/2010
3	Cholesterol Esters (Cholesteryl Esters)IBA 01/2011 - 09/2010
3	LDL CholesterolIBA 01/2011 - 09/2010
3	oxidized low density lipoproteinIBA 01/2011 - 09/2010
3	HDL CholesterolIBA 01/2011 - 09/2010
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 09/2002
2	Dietary ProteinsIBA 12/2019 - 03/2013
2	Aspartic Acid (Aspartate)FDA Link 12/2019 - 04/2004
2	Protein Isoforms (Isoforms)IBA 09/2015 - 04/2002
2	Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)IBA 09/2015 - 08/2007
2	OrnithineIBA 02/2013 - 12/2002
2	NAD (NADH)IBA 08/2007 - 05/2006
2	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 01/2004 - 07/2003
2	EnzymesIBA 07/2003 - 12/2002
1	CorticosteroneIBA 01/2023
1	CatecholaminesIBA 01/2023
1	Serum AlbuminIBA 01/2022
1	Capsules (Microcapsules)IBA 01/2022
1	CreatinineIBA 01/2022
1	Leptin ReceptorsIBA 05/2021
1	Oxidoreductases (Dehydrogenase)IBA 12/2019
1	Alanine (L-Alanine)FDA Link 12/2019
1	ThrombomodulinIBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	SodiumIBA 04/2017
1	Glycerol (Glycerine)FDA LinkGeneric 09/2015
1	alpha-glycerophosphoric acid (sodium glycerophosphate)IBA 09/2015
1	Biomarkers (Surrogate Marker)IBA 05/2015
1	Thiamine (Aneurin)FDA Link 01/2015
1	Dietary Fats (Dietary Fat)IBA 01/2015
1	OrexinsIBA 01/2015
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2015
1	Branched-Chain Amino AcidsIBA 09/2014
1	AdiponectinIBA 01/2014
1	Sodium CholateIBA 01/2014
1	Cadherins (E-Cadherin)IBA 03/2013
1	Oxygen (Dioxygen)IBA 03/2013
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 03/2013
1	Ethanol (Ethyl Alcohol)IBA 02/2013
1	Hydrocortisone (Cortisol)FDA LinkGeneric 02/2013
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 07/2012
1	DNA (Deoxyribonucleic Acid)IBA 01/2012
1	ferric nitrilotriacetateIBA 07/2011
1	pyruvate dehydrogenase kinase 4IBA 03/2011
1	Corticotropin-Releasing HormoneIBA 11/2009
1	acyl-ghrelinIBA 11/2009

Therapy/Procedure

1	Oral Administration 12/2019
1	Catheter Ablation 01/2019
1	High-Protein Low-Carbohydrate Diet (Atkins Diet) 02/2017
1	Hemodiafiltration 06/2009
1	Liver Transplantation 06/2009